Big toe blisters

When I was getting new blisters on the sides of my toes and on the bottoms of my feet, despite using the same type of shoes I'd been using for years, I decided to move up 1/2 size in shoes.  I was extremely hesitant because I'd been a 9.5 since I'd started running almost 4 years ago.  Haven't gone back down in size since the blisters disappeared.  

Two suggestions:

First, I agree with yeats, try a larger shoe.  I ended up doing the same thing.

Second, try putting body glide or some other lubricant over the affect area.  Once I started putting body glide on several areas of my feet, I stopped getting blisters.

Good luck!

Thanks for the suggestions. I do body glide... I think it probably helps a little, but it's not going to cut it for the longer runs.

As to bigger shoes... I wonder if I need wides. I'm in 10.5's now... I wear a 10 in most non-running shoes and just bought a pair of 9.5-wide Merrells. I can't imagine I need to go to an 11. I love my Peregrines for everything but this, but I guess I need to go back to the store and find something that doesn't rub me the wrong way.

It may not be the width of your shoe, but the height of the toe box. You might want to try the fit of some other shoes

Thanks, Nipper. I hadn't thought of that possibility. I'll keep that in mind when I get to a good running store.

I had same problems. Try Blister Shield (by Two Toms) powder in your socks. That helped a bit, but different socks totally cured the problem.  Expensive, but worth it for the trade off:

http://www.zombierunner.com/store/categories/clothing/socks/drymax/product1649.html 

I had tried the Injinji toe sox but they didnt seem to help.

Good luck