Road running in trail shoes--any disadvantage?

Not familiar with the Adrenaline specifically, but probably no big problem. You may find that the treads wear out a bit faster when you wear them on roads. The main issue is that trail runners tend to be a bit heavier and stiffer than road shoes, so they might feel like a bit of a drag. Sometimes if I'm on a holiday that involves trekking/hiking in SE Asia, I'll just bring my trail runners to hike in (my boots are too hot here) and a pair of Tevas, and maybe get in a few road runs before/after the trek. I've never had any problems with runs up to an hour, but I'd think twice about doing a long run in them, though, in case the greater stiffness bothered my feet or legs. Maybe because I'm fairly light, I find I have issues with a lot of hiking boots, or stiffer running shoes--they don't bend enough under my weight and change my natural stride, often giving me sore feet and calves. With a lighter trail shore, doubt you'd have this issue.

My basic take on any running shoe boils down to "If it feels good, do it".

I only wear trail shoes. My running is usally trails and dirt roads. However I do venture on to pavement and the trail shoes are fine, IMHO

I have Brooks Cascadia and I'll run on the road with them. I have noticed that they aren't as comfortable as my Brooks Defyance that I normally run with on the road. I haven't had any problems with it.

Trail shoes are kind of like mountain bikes. On one end of the mountain bike spectrum you have your dual suspension downhill race bike with 8 inches of travel in the fork and 3 inch knobby tires. On the other end of the spectrum you have your hardtail bike with 2 inches of travel and skinny 1.5 inch tires.

A proper trail shoe like a Montrail or a Solomon that is really good for trail running is going to be very harsh to run with on the road. It's like the equivelant of entering an on-road triathlon with a downhill race bike and a full-face helmet. These shoes are built with an indestructible upper and a rigid forefoot that allows you to run right over top of roots and pointy rocks.

If you want a trail shoe that is good for running on the road, usually you are safest to go with the trail version of a road shoe. (like the OP). You may even see the familiar word "hybrid" in the marketing materials and online reviews.

Like everything else, there is a trade-off with these hybrid shoes. For example, I wouldn't want to wear my flimsy Asics 2000 Trail shoes on the Baden Powel Trail across the north shore of Vancouver, but they are still great for running on the wheelchair acccesible trails in Stanley Park.

Used to run in the older Trail Responses and they were fine. I loved them so I ran about 1 1/2 years in them. 80+ mpw and they redefine. Only downside I found was the weight. If they are comfortable and you like them then do it.Dave

If you live in an area like me where even running on the paved road this time of year means running in snow and ice, trail shoes are fine. Trail shoes are usually heavier, but this is because they are designed to deal with changing terrain, much like you find in snowing, icy conditions. Just make sure they are big enough to accommodate warmer socks or you will be dealing with bigger issues.