Bike in the back of your SUV...

I don’t think you need to go as far as anchoring the bike, to.  I have a roof rack and a hitch mount, my car is used like a support vehicle so it is not unusual to drive around with 6 bikes in my car, but when I take only mine to the office to ride in the afternoons I just fold the back seat, lay it down with chain side up and that’s about it.  It doesn’t slide around and super easy to get it in and out.

You might want to get a cover to protect the back of the seat in case some grease rubs in, but besides that no special preparation.  I do all this in a Jeep Grand Cherokee that is not the biggest of SUVs

I have an 05 pathfinder and this is the solution I came up with to transport 2 bikes:

The rear passenger seats fold down and you can easily fit two bikes and all your gear.

YES.

Get a 2x6 cut to the width of the inside of your SUV. Buy a Yakima bedhead. Since it's inside you won't need the locking bedhead. Affix the bedhead to the 2x6.

Take the wheel off, roll the bike in, lock the fork to the bedhead. Done. Bike is standing up, and the board (if cut to the full width of the SUV) won't flip the bike.

If you're worried about the bike tilting throw your gym bag ontop of the board. I've had no problems with mine though.

This.  We just screwed generic fork mounts to a 2x4 cut to the width of the truck bed (under a cap, in our case).  We planned to bolt it to the bed floor, but never got around to it. It's nice to be able to easily remove the 2x4 when not in use and this means less damage to the inside of your car, too. 

I bought my RAV4 in large part because of the ease in which my bike fits. Drop down the "40" part of the 60-40 split rear seat and back it in. Doesn't budge while driving. No need to remove the front wheel or anything for that matter. I put a towel on the seat to protect it, drive train up and away from the seat.

For two bikes, I have two fork mounts mounted on a 1x6, and both seats are down.

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If one bike I just lay it down.

If two bikes I use a tie strap and stand them vertically against the side with the strap securing them to the roof-mounted handle meant to aid egress. This leaves the vast majority of the back available for other stuff.