knee injury

I am looking for a little advice, or anecdotal information on knee injuries. In the past, I have had chondramalacia in one of my knees, and then it went away. Lately, I have had a slight disconfort just above (and on the inside) of the right knee. It isn't pain so much as a little feeling that something isn't correct. I wear a knee strap, and sometimes it helps, and sometimes it does not. Any thoughts or past history here? I haven't stepped up mileage appreciably (less than 10% per week) nor changed much in the terms of workouts. Although, I have stepped down my weight lifting a fair amount, including the legs.

Thanks in advance for any insight.

Brendan