Genetic makeup => Ironman

I came across that while looking stuff up for my research. They found that a certain genetic combinations of the genes they studied had significant correlations to Ironman finishing time. Any Ironmane hopefuls out there want to get tested???

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Copy of the abstract:

The Bradykinin {beta}2 receptor (BDKRB2) and endothelial nitric oxide synthase 3(NOS3) genes and endurance performance during Ironman Triathlons.

Saunders CJ, Xenophontos SL, Cariolou MA, Anastassiades LC, Noakes TD, Collins M.

Department of Human Biology, University of Cape Town, South Africa.

We have previously shown that the insertion allele of the angiotensin converting enzyme (ACE) gene was over-represented in the fastest South African-born finishers of the South African Ironman Triathlons. Since ACE is a component of the skeletal muscle kallikrein-kinin system (KKS), the aim of this study was to determine if there are any further associations between polymorphisms within the BDKRB2 and NOS3 genes, which encode for the KKS components Bradykinin beta2 receptor and nitric oxide synthase respectively, and ultra-endurance performance during the Ironman Triathlons. Four hundred and forty-three male Caucasian triathletes who completed the 2000 and/or 2001 South African Ironman Triathlons and 203 healthy Caucasian male control subjects were genotyped for the functional -9/+9 polymorphism within exon 1 of the BDKRB2 gene and the G894T NOS3 gene polymorphism. The BDKRB2 -9/-9 genotype occurred at a significantly higher frequency when the triathlete group (27.0%) was compared to the control group (19.3%, P = 0.035). When divided into tertiles, there was also a significant linear trend for the NOS3 GG genotype distribution among the fastest (35.0%), middle (40.4%) and slowest (46.9%) finishers (P = 0.039). The overall finishing times of the triathletes with a NOS3 GG genotype together with a BDKRB2 +9 allele were significantly slower than those with other genotype combinations (P = 0.001). The NOS3/BDKRB2 genotype (beta = -0.150, beta = -31.48, P = 0.002), together with BMI and age, accounted for 14.6% of the variance in the overall race time for the triathlon. In conclusion both the NOS3 and BDKRB2 genes are associated with the actual performance during the Ironman Triathlons.