Saddle sore and moleskin? Little help?

I've developed a hot spot that is just a step away from becoming a saddle sore on my left side, and a 60 mile ride coming up this week.  This has only occurred after I upped my mileage and specifically first showed up after a ride that included a 45 minute 2200' climb.  Today was a 45 mile ride of rolling hills and smaller climbs, but the little beast was angrier than ever by the time I was done.  I've been consistent in lubing up the chamois with Chamois Butt'r, and that's what probably has held it at bay thus far. So:

1) I'm considering, for the long ride, slapping a large patch of moleskin over the reddened/roughened area to stave off an uncomfortable 3 hours.  I've used this for hot spots on the feet for marathon training, but don't know if this is the right answer for the sit bone.  Anyone tried this?  Other proven alternatives?

2) From what I've pulled up off the interweb, since this is happening only on one side, it may be either a saddle fit issue or, more likely, an uneven stroke.  When I had my fitting the fitter did indicate after watching me that I had a nice even stroke on the right side but a much more pronounced downstroke on the left, so it sounds like some single leg drills may be in order.  Opinions?